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our protocol include the use of room temperature and
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By reinvestigating K2S2O8-mediated organic reactions that
invariably require higher temperature and an organic solvent,
we have developed a mild, green strategy for the diverse
synthesis and functionalization of N-heterocycles at room
temperature in water using inexpensive K2S2O8 as the primary
reagent. Unlike traditional methods used for persulfate activa-
tion, the current method uses glucose as theꢀpersulfate activa-
tor at room tempꢀerature to generate SO4 ꢁ. Although the
involvement of SO4 ꢁ in these organic transformation is likely,
whether the mechanisms of all of these transformations mirror
those reported in the original literature remains a question.
Further applications of this protocol and the underlying mecha-
nism are currently under investigation.
M. K. H. performed all experimentation and manuscript
preparation. J. K. L. was involved in the inception of the
concept, manuscript preparation and editing.
The generous funding of the project by SERB, New Delhi is
greatly appreciated (award no. CRG/2020/000462). M. K. H.
thanks the NIPER S.A.S. Nagar for a research fellowship.
ˇ
´
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Conflicts of interest
There are no conflicts to declare.
Notes and references
1 See review on oxidative C–H functionalization: (a) C. Zheng and
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8440 | Chem. Commun., 2021, 57, 8437–8440
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