Trifluoromethylated 3-(Pyrazol-1-yl)propanamide (PPA) Ligands

Article abstract of DOI:10.1002/hlca.202000148

The new PPA ligands 3-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]propanamide (CF₃MePPA; 3) and 3-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]propanamide ((CF₃)₂PPA; 4) were synthesized by Aza-Michael addition of the specific pyrazole derivatives to acrylamide. Both products were characterized by elemental analyses, IR and NMR spectroscopy, and mass spectrometry. X-Ray structure determination of 3 revealed the presence of a one-dimensional hydrogen-bonded structure in the solid state. The ligating ability of the new ligands towards PdCl₂ was studied, showing that 3 behaves similar to Me₂PPA and reacts cleanly with PdCl₂ to afford the sparingly soluble complex PdCl₂(CF₃MePPA-κN)₂. By contrast, the donor ability of pyrazolyl group in 4 was found to be considerably reduced, thus resulting in the formation of the unusual complex PdCl₂{(CF₃)₂PPA-κN}{(CF₃)₂PPA-κO}.

Full text of DOI:10.1002/hlca.202000148

HELVETICA
chimica acta
Accepted Article
Title: Trifluoromethylated 3-(Pyrazol-1-yl)-Propanamide (PPA) Ligands
Authors: Phil Liebing and Frank T. Edelmann
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To be cited as: Helv. Chim. Acta 10.1002/hlca.202000148
Link to VoR: https://doi.org/10.1002/hlca.202000148
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10.1002/hlca.202000148
Helvetica Chimica Acta
This article is protected by copyright. All rights reserved.

10.1002/hlca.202000148
Helvetica Chimica Acta
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10.1002/hlca.202000148
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10.1002/hlca.202000148
Helvetica Chimica Acta
This article is protected by copyright. All rights reserved.

10.1002/hlca.202000148
Helvetica Chimica Acta
This article is protected by copyright. All rights reserved.