SCHIZONELLIN A AND B, NEW GLYCOLIPIDS FROM SCHIZONELLA MELANOGRAMMA

Article abstract of DOI:10.1016/0031-9422(80)85018-7

Two new glycolipids, schizonellin A and B, were isolated from cultures of the smut fungus Schizonella melanogramma.Their structures were elucidated by chemical degradation and spectroscopic methods.The schizonellins are active against Gram-positive bacteria, as well as against some Gram-negative bacteria and some fungi.DNA-, RNA- and protein-syntheses in Erhlich carcinoma ascitic cells are inhibited simultaneously after addition of the schizonellins.Strong haemolytic action on bovine erythrocytes was observed.Key Word Index - Schizonella melanogramma; Basidiomycetes; smut fungi; anti biotics; glycolipids; schizonellins.