Structure-activity relationship for DNA topoisomerase II-induced DNA cleavage by azatoxin analogues

DOI: 10.1016/S0968-0896(97)00113-2

Source and publish data:

Bioorganic and Medicinal Chemistry p. 1807 - 1815 (1997)

Update date:2022-08-04

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Authors:

Madalengoitia, Jose S.

Tepe, Jetze J.

Werbovetz, Karl A.

Lehnert, Erich K.

Macdonald, Timothy L.

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Article abstract of DOI:10.1016/S0968-0896(97)00113-2

Eighteen analogues of the nonintercalative DNA topoisomerase II (topo II)-active epipodophyllotoxin-ellipticine hybrid, azatoxin, were synthesized and evaluated for their ability to induce topo II-mediated DNA strand breaks in vitro. In general, the SAR p

Full text of DOI:10.1016/S0968-0896(97)00113-2

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