12 Nucleic Acids Research, 2015
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gen bonds with the T-A base pair in a triplex and stabilizes
the structures of triplexes. Consequently, we successfully
DA
synthesized a fully modified TFO containing Nac, dgC,
sT and
sA with high binding and base recogni-
2’-OMe
2’-OMe
tion abilities. These results should be very useful for nan-
otechnology and gene therapy using TFOs. Further studies
are now underway in those directions.
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SUPPLEMENTARY DATA
ACKNOWLEDGEMENT
This study was supported by a Grant-in-Aid for Scientific
Research from the Ministry of Education, Culture, Sports,
Science and Technology, Japan.
FUNDING
Funding for open access charge: Grant-in-Aid for Scientific
Research from the Ministry of Education, Culture, Sports,
Science and Technology, Japan.
Conflict of interest statement. None declared.
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