Synthesis and triplex-forming properties of oligonucleotides capable of recognizing corresponding DNA duplexes containing four base pairs

DOI: 10.1093/nar/gkv496

Source and publish data:

Nucleic Acids Research p. 5675 - 5686 (2015)

Update date:2022-08-11

Topics:

Authors:

Ohkubo, Akihiro

Yamada, Kenji

Ito, Yu Ito, Yu

Yoshimura, Kiichi

Miyauchi, Koichiro

Kanamori, Takashi

Masaki, Yoshiaki

Seio, Kohji

Yuasa, Hideya

Sekine, Mitsuo

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Article abstract of DOI:10.1093/nar/gkv496

A triplex-forming oligonucleotide (TFO) could be a useful molecular tool for gene therapy and specific gene modification. However, unmodified TFOs have two serious drawbacks: low binding affinities and high sequence-dependencies. In this paper, we propose

Full text of DOI:10.1093/nar/gkv496

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