One-pot preparation of 1H-naphtho[2,3-c]pyran-5,10-diones and its application to concise total synthesis of (±)-eleutherin and (±)- isoeleutherin

Article abstract of DOI:10.1016/S0040-4039(98)01683-9

1H-Naphtho[2,3-c]pyran-5,10-dione derivatives, including a natural product (pentalongin), were generally synthesized in one-pot using a tandem conjugate addition-cyclization sequence between 2-(1-hydroxyalkyl)-1,4- naphthoquinones and enamines (or imines)