COMMUNICATIONS
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Experimental Section
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General Conditions for the Synthesis of 6-Substituted
4-Sulfonamidoquinoline-2-ones 2a, e–q under Batch
Microwave Conditions
To a stirred mixture of the corresponding alkynyl amide 1a,
e–q (0.3 mmol) and 1.5 mL dichloroethane (DCE) in a 5-
mL Pyrex microwave vial, equipped with a magnetic stir
bar, Cu(OAc)2 (ca. 6 mg, 0.03 mmol, 10 mol%, 0.1 equiv.),
tosyl azide (TsN3, 555 mL, 0.31 mmol, 1.05 equiv., 11–15%
w/w solution in toluene) and powdered Nafionꢁ NR50
(10 mg, particle size ꢀ 250 mm, ꢁ 0.8 mequiv./g ion exchange
capacity) were added. The reaction mixture was capped
with a Teflon septum, stirred for 10 s and subjected to mi-
crowave heating for 10 min (fixed hold time) at 1508C and
subsequently cooled to 508C. The resulting reaction mixture
was concentrated under reduced pressure and the residue
purified by flash chromatography (CHCl3:CH3OH=9:1) to
afford 6-substituted 4-sulfonamidoquinoline-2-ones 2a, e–q.
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Acknowledgements
This research was supported by a grant from the Christian
Doppler Research Association (CDG).
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