Ligand-Free Copper-Catalyzed N-Arylation of Nitrogen Nucleophiles
Table 3. Cu2O-catalyzed N-arylation of pyrazole with differ-
COMMUNICATIONS
References
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Entry ArX
1
Product
Yield
[%][a]
4a 98 (X=I)
93 (X=Br)
0 (X=Cl)
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2
3
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4
5
4d 99
4b 99[b]
6
4e 91[b]
7
8
4f 98[b]
4g 95[b]
4h 98[b]
9
[a]
Yield of isolated product by flash chromatography.
[b]
The reaction was carried out at 1108C.
the product was confirmed by Hand 13C NMR spectroscop-
ic analysis, see Supporting Information for full details.
1
Acknowledgements
The authors are grateful to the Fonds der Chemischen Indus-
trie for financial support. A. C. thanks the Basque Govern-
ment for being supported by ꢀPrograma de Perfeccionamien-
to de Doctores en el extranjero del Departamento de Educa-
ción, Universidades e Investigación’.
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Adv. Synth. Catal. 2007, 349, 2673 – 2676
ꢀ 2007 Wiley-VCHVerlag GmbH& Co. KGaA, Weinheim
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