A new method for deprotection of benzothiazolesulfonamides using a thiol and base

DOI: 10.1016/S0040-4039(98)02107-8

Source and publish data:

Tetrahedron Letters p. 9155 - 9156 (1998)

Update date:2022-08-11

Topics:

Authors:

Wuts, Peter G. M.

Gu, Rui Lin

Northuis, Jill M.

Thomas, Collette L.

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Article abstract of DOI:10.1016/S0040-4039(98)02107-8

Benzothiazolesulfonamides of primary and secondary amines are efficiently cleaved by a nucleophilic aromatic substitution with a thiol and a base such as potassium t-butoxide or diisopropylethyl amine in DMF.

Full text of DOI:10.1016/S0040-4039(98)02107-8

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