PERFLUOROALKYLATED MONOESTERS OF 1,4-D-SORBITAN, ISOSORBIDE AND ISOMANNIDE: NEW SURFACTANTS FOR BIOMEDICAL APPLICATIONS

Article abstract of DOI:10.1016/S0022-1139(00)84372-9

A one step selective synthesis of pure 1,4-D-Sorbitan monoesters 4 was achieved by treating 1,4-D-Sorbitan 1 with R_F9CH2)_nCOCl (R_F=C4F9, C5F11, C8F17; n=2, 10) in pyridine at room temperature. (13)C NMR establishes that esterification occured on carbon 6 only.While isomannide, 3, gives only one monoester, 8, the less symmetrical isosorbide 2 leads to two monoesters displaying significantly different physical properties.These compounds display moderate surface activities and do not perturb the growth and viability of Namalva lymphoblastold cell cultures.