Journal of Heterocyclic Chemistry p. 1143 - 1147 (1992)
Update date:2022-08-17
Topics:
Kuroda
Hisamura
Nakamizo
Otsuji
2'-Deoxy-5-fluorouridine (5-FUdR) derivatives having various types of sulfur-containing substituents at the 5'-O-position were synthesized and their γ-radiolyses were studied in aqueous solutions. The γ-radiolysis of compounds having 1,3-dithiol-2-yl and 1,3-dithian-2-yl substituents at the 5'-O-position efficiently gave 5-FUdR, specifically via the attack of hydroxyl radical. On the other hand, the γ-radiolysis of a compound having a sulfonylmethyl substituent at the 5'-O-position gave less efficiently 5-FUdR, specifically via the attack of the hydrated electron. The mechanistic features of these reactions are discussed.
View MoreJiangsu Cale New Material Co.ltd
Contact:+86-515-88334667/88203550
Address:Zhongshan 3rd Road, Coastal Chemical Industry Park, Yancheng, Jiangsu, China
Suzhou Sibian Chemical Technology Co., Ltd
website:http://www.sibianpharm.com
Contact:+8618169181984,+8618013186906
Address:Room1404,BuildingA,Jiabao Square No.323 Baodai East Road,Wuzhong District,Suzhou Jiangsu China (215128)
SHAANXI TOP PHARM CHEMICAL CO.LTD
Contact:+86-029-85733403
Address:No.108 ,west sector,south er huan,xi'an,china
Junkai (Tianjin) Chemical Co., Ltd.
website:http://www.junkaichem.com
Contact:86-22-85689515
Address:Room 8-501, Building K2, The Hi-Tech Green Industrial Base, No.6, 6th Road, Hi-Tech Development Road, Tianjin Hi-Tech IndustrialPark, Tianjin, China.
Contact:+86-21-56338808
Address:799 Dunhuang Road, Putuo
Doi:10.1016/j.cattod.2010.10.049
(2011)Doi:10.1021/np200604k
(2012)Doi:10.1021/ja01176a025
(1949)Doi:10.1016/S0020-1693(00)84855-0
(1990)Doi:10.1016/j.tetlet.2006.10.156
(2007)Doi:10.1007/BF00700906
(1995)