Nucleosides and Nucleotides p. 1079 - 1082 (1999)
Update date:2022-08-11
Topics:
Busson
Kerremans
Van Aerschot
Peeters
Blaton
Herdewijn
In contrast with the behaviour of 5-unsubstituted cytosine nucleoside analogues, 5-methylcytosine derivatives show upon N4-benzoylation, commonly used as base protection in oligonucleotide synthesis, a tautomeric change of the base moiety from a 4-amino- into a 4-imino isomer. In the latter form, which is easily diagnosticized by 13C NMR and confirmed by X-ray data, the compounds seem to be hydrolytically less stable.
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