A short and efficient enantioselective synthesis of cyclohexylnorstatine, a key component of a renin inhibitor

Article abstract of DOI:10.1016/S0957-4166(97)00500-4

A catalytic asymmetric synthesis of ethyl (2R,35)-N-(p- toluenesulfonyl)-3-amino-4-cyclohexyl-2-hydroxybutyrate 7 in 96% ee from cheaply available cyclohexanone is described employing Sharpless asymmetric aminohydroxylation as the key step.