A short and efficient enantioselective synthesis of cyclohexylnorstatine, a key component of a renin inhibitor

DOI: 10.1016/S0957-4166(97)00500-4

Source and publish data:

Tetrahedron Asymmetry p. 3685 - 3689 (1997)

Update date:2022-08-24

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Authors:

Upadhya Upadhya

Sudalai Sudalai

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Article abstract of DOI:10.1016/S0957-4166(97)00500-4

A catalytic asymmetric synthesis of ethyl (2R,35)-N-(p- toluenesulfonyl)-3-amino-4-cyclohexyl-2-hydroxybutyrate 7 in 96% ee from cheaply available cyclohexanone is described employing Sharpless asymmetric aminohydroxylation as the key step.

Full text of DOI:10.1016/S0957-4166(97)00500-4

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Product name:2-Butenoic acid, 4-cyclohexyl-, ethyl ester, (2E)-

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