Nucleosides and Nucleotides p. 1019 - 1020 (1999)
Update date:2022-08-16
Topics:
Pochet, Sylvie
Beaussire, Jean-Jacques
Dugue, Laurence
Marliere, Philippe
The synthesis of phosphoric esters linking the 5' alcohol of thymidine to the alcohol moiety of L-serine derivatives is reported, together with the pyridoxal-catalyzed β-elimination reaction releasing thymidylate from such compounds. The process was extended to the release of thymidine di- and tri- phosphate.
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