SYNTHESE D'ANTIBIOTIQUES TRITERPENIQUES A PARTIR D'ACIDES BILIAIRES. IV . ETUDE DE L'HYDROGENATION CATALYTIQUE DU DIMETHYL-4,4 CHOLENE-5 ONE-3 OATE-24 DE METHYLE.

Article abstract of DOI:10.1016/S0040-4020(01)83455-4

Catalytic hydrogenation of methyl 4,4 dimethyl chol-5 en-3-one-24 oate, prepared from lithocholic acid has been carefully studied in a variety of conditions (solvent, temperature, pressure, nature and amount of catalyst) .Fairly mild conditions have been found, which lead to the 5α dihydroderivative, and do not affect the Δ⁸⁽⁹⁾ double bond of lanosterol.Therefore, one of the major difficulties of the conversion of bile acids into tetracyclic triterpene antibiotics has been overcome .