High-turnover aminopyridine-based Pd-catalysts for Suzuki-Miyaura reaction in aqueous media

Article abstract of DOI:10.1016/j.catcom.2016.02.016

A high-turnover catalytic system based on commercially available aminopyridines (L) and PdCl₂ has been developed for Suzuki-Miyaura reaction in aqueous media. Reactions of arylboronic acids with a wide range of aryl iodides, bromides and chlorides proceeded in the presence of these catalysts for a short time in aqueous media to afford the cross-coupling products in high yields. Furthermore, this protocol allows tolerating a wide range of functional groups.