Enzymatic method of preparation of opticallly active trans-2-amino cyclohexanol derivatives

Article abstract of DOI:10.1080/00397919908086112

Supported Lipase Amano PS-D catalyzes the resolution of (±)-trans-2- tert butoxycarbonyl amino cyclohexanol by a selective acylation reaction. Using the supported enzyme gave a much faster reaction compared to existing methodology on similar substrates. A variety of acylating agents were investigated, with vinyl acetate providing the most practical and convenient procedure.

Full text of DOI:10.1080/00397919908086112

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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Enzymatic Method of
Preparation of Opticallly Active
Trans-2-Amtno Cyclohexanol
Derivatives
a
a
a
A. Ursini , P. Maragni , C. Bismara & B.
a
Tamburini
a
Glaxo Wellcome Research Centre, Chemical
Development Department , Via A. Fleming, 4,
Verona, Italy
Published online: 17 Sep 2007.
To cite this article: A. Ursini , P. Maragni , C. Bismara & B. Tamburini (1999)
Enzymatic Method of Preparation of Opticallly Active Trans-2-Amtno Cyclohexanol
Derivatives, Synthetic Communications: An International Journal for Rapid
Communication of Synthetic Organic Chemistry, 29:8, 1369-1377, DOI:
10.1080/00397919908086112
To link to this article: http://dx.doi.org/10.1080/00397919908086112
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