Organic Letters
Letter
In summary, we have reported the first cobalt-catalyzed α-
alkylation of ketones with primary alcohols through a hydrogen-
borrowing method. The cobalt catalyst proved to be not only
effective for the C−C bond-forming between a variety of ketones
and a range of alcohols as alkylating reagents but also applicable
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ASSOCIATED CONTENT
Supporting Information
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AUTHOR INFORMATION
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*
ORCID
1
1
1
2360. (g) Guo, J.; Lu, Z. Angew. Chem., Int. Ed. 2016, 55, 10835−
0838. (h) Zuo, Z.; Yang, J.; Huang, Z. Angew. Chem., Int. Ed. 2016, 55,
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Notes
The authors declare no competing financial interest.
(7) (a) Zuo, W.; Morris, R. H. Nat. Protoc. 2015, 10, 241−257.
(
b) Mikhailine, A. A.; Maishan, M. I.; Lough, A. J.; Morris, R. H. J. Am.
ACKNOWLEDGMENTS
We are grateful to donors of the American Chemical Society
Petroleum Research Fund for partial support of this work
Chem. Soc. 2012, 134, 12266−12280. (c) Mikhailine, A. A.; Maishan, M.
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I.; Morris, R. H. Org. Lett. 2012, 14, 4638−4641.
(8) (a) Mukhopadhyay, T. K.; Flores, M.; Groy, T. L.; Trovitch, R. J. J.
Am. Chem. Soc. 2014, 136, 882−885. (b) Nerush, A.; Vogt, M.; Gellrich,
U.; Leitus, G.; Ben-David, Y.; Milstein, D. J. Am. Chem. Soc. 2016, 138,
(
54247-UNI3). We also acknowledge support from CUNY
Collaborative Research Incentive Program, the PSC−CUNY
award (69069-0047), and a “Seed Grant” from the Office for the
Advancement of Research at John Jay College, CUNY. Partial
support from the National Science Foundation (CHE-1464543)
is also gratefully acknowledged.
6
985−6997. (c) Elangovan, S.; Topf, C.; Fischer, S.; Jiao, H.;
Spannenberg, A.; Baumann, W.; Ludwig, R.; Junge, K.; Beller, M. J.
Am. Chem. Soc. 2016, 138, 8809−8814. (d) Mukherjee, A.; Nerush, A.;
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