Synthesis of ribonucleoside 3',5'-cyclic phosphorothioates using a modified hydroxybenzotriazole phosphotriester approach

Article abstract of DOI:10.1002/recl.19871061106

Phosphorothioylation of 3',5'-dihydroxy ribonucleosides with O-(2-chlorophenyl) O,O-bis<6-(trifluoromethyl)-1-benzotriazolyl> phosphorothioate, followed by addition of N-methylimidazole and removal of protecting groups, gives ribonucleosides 3',5'-cyclic