A new synthesis of roxatidine acetate

Article abstract of DOI:10.1080/00397919908085729

A new four-step synthesis of N-{3-[3-(1-piperidinylmethyl)- phenoxy]propyl}acetoxyacetamide hydrochloride has been performed. The key aralkyl ether was synthesized in high yield under moderate conditions. A suitable scaling up permits a bulky production of the drug in 98.5% purity.

Full text of DOI:10.1080/00397919908085729

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Synthetic Communications: An
International Journal for Rapid
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Organic Chemistry
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A New Synthesis of Roxatidine
Acetate
a
a
Velichko Tarpanov , Radoslav Vlahov , Miho
a
a
a
Penkov , Dikran Krikorian , Stoyan Parushev
a
b
,
Pepa Mechkarova , Nely Angelova & Walter
c
Schunack
a
Institute of Organic Chemistry with Centre of
Phytochemistry, Bulgarian Academy of Sciences ,
1
113, Sofia, Bulgaria
b
Institute for Antibiotic Research, “Antibiotic” Co ,
Razgrad, Bulgaria
c
Institut fur Pharmazie, Freie Universitat Berlin ,
Königin-Luise-Str.2+4, 14195, Berlin, Germany
Published online: 17 Sep 2007.
To cite this article: Velichko Tarpanov , Radoslav Vlahov , Miho Penkov , Dikran
Krikorian , Stoyan Parushev , Pepa Mechkarova , Nely Angelova & Walter Schunack
(
1999) A New Synthesis of Roxatidine Acetate, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry, 29:1,
5-20, DOI: 10.1080/00397919908085729
1
To link to this article: http://dx.doi.org/10.1080/00397919908085729
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