Il Farmaco p. 73 - 79 (1999)
Update date:2022-08-11
Topics:
Amoroso, Rosa
Bettoni, Giancarlo
Tricca, Maria Luisa
Loiodice, Fulvio
Ferorelli, Savina
This paper describes a simple procedure for the resolution of racemic α-monoalkyl α-aryloxyacetic acids, using the chromatographic separation of their covalent derivatives. (R)-Ethyl mandelate, (R)-pantolactone and (S)-4-(1-methylethyl)-2-oxazolidinone are the resolving agents involved in the formation of equimolecular diastereomeric mixtures of esters or imides. Chromatographic resolutions were performed by means of gas chromatography (GC), thin-layer chromatography (TLC) and flash chromatography. Successive hydrolysis of separated diastereomers provided optically pure aryloxyacetic acids.
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