4
Tetrahedron
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Heterocycles 2015, 91, 537–549.
6-hexatriene system followed by the Sharpless asymmetric
dihydroxylation as the key step. Furthermore, the absolute
configuration of natural (+)-asiaticumine A (2) was determined to
be S. In addition, the biological activities of (+)-2, its enantiomer,
and their derivatives are under evaluation.
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Hibino, S. Chem. Pharm. Bull. 2008, 56, 237–238; b) Tagawa, S.;
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Choshi, T. Heterocycles 2018, 97, 383–394.
Acknowledgments
This work was supported in part by a Grant-in Aid for
Scientific Research (C) of the Japan Society for the Promotion of
Science (grant number 15K07880 for T. C. and 17K08369 for N.
H.).
[12] Kumemura, T.; Choshi, T.; Yukawa, J.; Hirose, A.; Nobuhiro, J.;
Hibino, S. Heterocycles 2005, 66, 87–90.
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(+)-2-(R)-MTPA ester [(+)-1-(8,9-methylenedioxyphenanthridin-4-
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(R)-α-methoxy-α-
(trifluoromethyl)phenylacetate]:1H-NMR (300 MHz, CDCl3) 0.08
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()-2-(S)-MTPA ester [()-1-(8,9-methylenedioxyphenanthridin-4-
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