Synthesis of optically active O-protected (S)- and (R)-3-hydroxyaldehydes

Article abstract of DOI:10.1016/S0040-4039(00)92630-3

(S)-3-Formyloxyaldehydes, chiral synthons for natural product synthesis were synthesized via highly stereoselective hydrogenation of the unsaturated furanose ring system derived from D-glucose or D-xylose. Alternatively, (R)-3-formyloxyaldehydes were prepared via deoxygenation of 3-hydroxyfuranoses derived from D-glucose or D-xylose.