An improved oxadiazole synthesis using peptide coupling reagents

Article abstract of DOI:10.1016/S0040-4039(96)01492-X

Substituted 1,2,4-oxadiazoles were synthesized in good yields in a one pot procedure by condensation of the corresponding amidoxime with carboxylic acids in the presence of a peptide coupling reagent in diglyme, followed by heating the reaction mixture to 100°C for several hours.