One-Electron Redox Potentials of Purines and Pyrimidines

Article abstract of DOI:10.1021/j100277a053

One-electron redox potentials of some purine and pyrimidine derivatives were determined by pulse radiolysis from electron transfer equilibria involving their and other free radicals.The redox potentials were determined at pH 13 by using p-methoxyphenol (E=0.4 V), Trolox C (E=0.19 V), and tryptophan (E=0.56 V) as references.The lowest oxidation potential measured for DNA bases was guanosine (E=0.72 V vs.NHE), and the highest was for 1-methylpyrimidines (E ca. 1.6 V) Uric acid (E=0.26 V) and isobarbituric acid (E=0.13 V) were found to have the lowest potentials.