An improved synthesis of 2-chlorinated imidazo[1,2-a]pyridines and the application of this procedure for the synthesis of several new polychlorinated imidazo[1,2-a]pyridines

Article abstract of DOI:10.1080/00397919708004089

Polychlorinated imidazo[1,2-a]pyridines were synthesized as analogs of certain chlorinated benzimidazoles. The imidazo[1,2-a]pyridines were obtained by a condensation of ethyl bromoacetate and chlorinated 2-aminopyridines. These condensation products were treated with an ion exchange resin to effect an exchange of hydrobromide salts with hydrochloride salts. These compounds were subsequently treated with POCl₃ to convert the imidazo[1,2-a]pyridin-2-ones into 2-chloroimidazo[1,2-a]pyridines.

Full text of DOI:10.1080/00397919708004089

This article was downloaded by: [Georgetown University]
On: 11 June 2013, At: 23:15
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954
Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH,
UK
Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
Publication details, including instructions for
authors and subscription information:
http://www.tandfonline.com/loi/lsyc20
An Improved Synthesis of 2-
Chlorinated Imidazo[1,2-α]-
pyridines and the Application
of this Procedure for
the Synthesis of Several
New Polychlorinated
Imidazo[1,2-α]Pyridnes.
a
a
Kristjan S. Gudmundsson , John C. Drach & Leroy
a
B. Townsend
a
Department of Medicinal Chemistry, College of
Pharmacy and Department of Chemistry, College of
Literature, Science and the Arts, The University of
Michigan, Ann Arbor, MI, 48109-1065
Published online: 22 Aug 2006.
To cite this article: Kristjan S. Gudmundsson , John C. Drach & Leroy B. Townsend
(1997): An Improved Synthesis of 2-Chlorinated Imidazo[1,2-α]-pyridines and the
Application of this Procedure for the Synthesis of Several New Polychlorinated
Imidazo[1,2-α]Pyridnes., Synthetic Communications: An International Journal for
Rapid Communication of Synthetic Organic Chemistry, 27:10, 1763-1775
To link to this article: http://dx.doi.org/10.1080/00397919708004089
PLEASE SCROLL DOWN FOR ARTICLE

Full terms and conditions of use: http://www.tandfonline.com/page/terms-
and-conditions
This article may be used for research, teaching, and private study purposes.
Any substantial or systematic reproduction, redistribution, reselling, loan,
sub-licensing, systematic supply, or distribution in any form to anyone is
expressly forbidden.
The publisher does not give any warranty express or implied or make any
representation that the contents will be complete or accurate or up to
date. The accuracy of any instructions, formulae, and drug doses should be
independently verified with primary sources. The publisher shall not be liable
for any loss, actions, claims, proceedings, demand, or costs or damages
whatsoever or howsoever caused arising directly or indirectly in connection
with or arising out of the use of this material.