Antioxidative activity of tetrahydrocurcuminoids.

Article abstract of DOI:10.1271/bbb.59.1609

In order to develop a new type of antioxidative compound which has both the phenolic and beta-diketone moiety in the same molecule, we converted three known curcuminoids, curcumin (diferuloylmethane, U1), (4-hydroxy-3-methoxycinnamoyl)methane (U2), and bis-(4-hydroxycinnamoyl)methane (U3), which are the natural antioxidants of Curcuma longa L. (tumeric), to tetrahydrocurcuminoids (THU1, THU2, and THU3, respectively) by hydrogenation, and evaluated their antioxidative activity by using linoleic acid as the substrate in an ethanol/water system. Further, we used the rabbit erythrocyte membrane ghost and rat liver microsome as in vitro systems and determined the antioxidative activity of these curcuminoids. When we evaluated their antioxidative activity by these assays, it was found that THU1 had the strongest antioxidative activity among all curcuminoids in each assay system. THU1 has been reported to be one of the main metabolites of U1 in vivo [Holder et al., Xenobiotica, 8, 761-768 (1978)]. These results suggest that THU1 must play an important role in the antioxidative mechanism of U1 in vivo by converting U1 into THU1.

Full text of DOI:10.1271/bbb.59.1609

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Antioxidative Activity of Tetrahydrocurcuminoids
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Toshihiko Osawa , Yasunori Sugiyama , Masanori Inayoshi & Shunro Kawakishi
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Laboratory of Food and Biodynamics, Department of Applied Biological Sciences,
Nagoya University, Nagoya 464–01, Japan
Published online: 12 Jun 2014.
To cite this article: Toshihiko Osawa, Yasunori Sugiyama, Masanori Inayoshi & Shunro Kawakishi (1995) Antioxidative
Activity of Tetrahydrocurcuminoids, Bioscience, Biotechnology, and Biochemistry, 59:9, 1609-1612, DOI: 10.1271/
bbb.59.1609
To link to this article: http://dx.doi.org/10.1271/bbb.59.1609
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