Tetrahedron Letters p. 1635 - 1637 (2018)
Update date:2022-08-11
Topics:
Brocklesby, Kayleigh L.
Waby, Jennifer S.
Cawthorne, Christopher
Smith, Graham
Fluorine substitution is an established tool in medicinal chemistry to favourably alter the molecular properties of a lead compound of interest. However, gaps still exist in the library of synthetic methods for accessing certain fluorine-substituted motifs. One such area is the fluoromethyl group, particularly when required in a fluoroalkylating capacity. The cold fluorination of methylene ditosylate is under evaluated in the literature, often proceeding with low yields or harsh conditions. This report describes a novel microwave method for the rapid nucleophilic fluorination of methylene ditosylate using inexpensive reagents in good isolated yield (65%).
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Doi:10.1021/jf971101s
(1998)Doi:10.1039/c6dt00676k
(2016)Doi:10.1055/s-2001-16802
(2001)Doi:10.1039/c4nj02021a
(2015)Doi:10.1007/BF00630430
(1992)Doi:10.1016/j.tetlet.2020.151973
(2020)