Bioorganic and Medicinal Chemistry Letters p. 2149 - 2152 (2000)
Update date:2022-08-16
Topics:
Paul, Gitendra C.
De Clercq, Erik
Pannecouque, Christophe
Witvrouw, Myriam
Loftus, Tracy L.
Turpin, Jim A.
Buckheit Jr., Robert W.
Cushman, Mark
The binding of the anti-HIV agent cosalane to CD4 is thought to involve ionic interactions of negatively charged carboxylates of the ligand with positively charged residues on the surface of the protein. An investigation of the optimal anion distances for anti-HIV activity in a series of cosalane tetracarboxylate analogues has been completed, and maximal activity results when the two proximal and the two distal carboxylates are separated by eight atoms. (C) 2000 Elsevier Science Ltd.
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