SYNTHESIS OF N-TERT-BUTYL-α-(4-FLUOROPHENYL)NITRONE (FPBN) FOR IN VIVO DETECTION OF FREE RADICALS

Article abstract of DOI:10.1002/jlcr.2580360202

We have synthesized the fluorine-18 labeled derivative of N-tert-butyl-α-phenylnitrone (PBN), a free radical spin trapping agent widely used with electron spin resonance (ESR).N-tert-Butyl-α-(4-<18F>fluorophenyl)nitrone (<18F>FPBN) could be prepared with