Absolute stereochemistry of vicenistatin, a novel 20-membered macrocyclic lactam antitumor antibiotic

Article abstract of DOI:10.1016/S0040-4039(98)00454-7

The absolute stereochemistry of the aglycon part of an antitumor antibiotic vicenistatin (1) was determined by a synthetic approach. Two relevant components degradatively derived from natural 1 were compared with the corresponding synthetic standards prepared from known compounds by stereochemically defined chemistry. The absolute configuration of 1 turned out to be 6S,7S,18S.