115458-82-7Relevant academic research and scientific papers
Absolute stereochemistry of vicenistatin, a novel 20-membered macrocyclic lactam antitumor antibiotic
Arai, Hiroko,Matsushima, Yoshitaka,Eguchi, Tadashi,Shindo, Kazutoshi,Kakinuma, Katsumi
, p. 3181 - 3184 (1998)
The absolute stereochemistry of the aglycon part of an antitumor antibiotic vicenistatin (1) was determined by a synthetic approach. Two relevant components degradatively derived from natural 1 were compared with the corresponding synthetic standards prepared from known compounds by stereochemically defined chemistry. The absolute configuration of 1 turned out to be 6S,7S,18S.
Catalytic diastereoselective reduction of α,β-epoxy and α,β-aziridinyl ynones
Druais, Valerie,Meyer, Christophe,Cossy, Janine
supporting information; scheme or table, p. 516 - 519 (2012/03/26)
The Noyori transfer hydrogenation of α,β-epoxy and α,β-aziridinyl ynones leads to the corresponding α,β-epoxy or α,β-aziridinyl propargylic alcohols with high reagent-controlled diastereoselectivity.
Total synthesis of (-)-baconipyrone C
Yadav,Sathaiah,Srinivas
experimental part, p. 3545 - 3552 (2009/09/25)
A highly stereoselective asymmetric total synthesis of marine polypropionate (-)-baconipyrone C has been achieved. Utilization of desymmetrization technique to create five stereogenic centres, Sharpless epoxidation, Gilman's reaction and resolution of met
Total synthesis of scytophycin C. 1. Stereoselective syntheses of the C(1)-C(18) segment and the C(19)-C(31) segment
Nakamura, Ryoichi,Tanino, Keiji,Miyashita, Masaaki
, p. 3579 - 3582 (2007/10/03)
[Equation presented] Stereoselective total synthesis of scytophycin C, a marine 22-membered macrolide displaying potent activity against a variety of human carcinoma cell lines, has been reported in which the polypropionate structure bearing contiguous as
Synthetic Studies on Polypropionate Antibiotics Based on the Stereospecific Methylation of γ,δ-Epoxy Acrylates by Trimethylaluminum. A Highly Stereoselective Construction of the Eight Contiguous Chiral Centers of Ansa-chains of Rifamycins
Miyashita, Masaaki,Yoshihara, Kousei,Kawamine, Katsumi,Hoshino, Masahide,Irie, Hiroshi
, p. 6285 - 6288 (2007/10/02)
A highly stereoselective construction of the eight contiguous chiral centers of ansa-chains of rifamycins has been accomplished by the iterative use of the stereospecific methylation of γ,δ-epoxy acrylates by trimethylaluminum which was recently developed
NEW ALLYLSTANNANES FOR THE CONNECTIVE CONSTRUCTION OF MONOPROTECTED VICINAL DIOLS
Keck, Gary E.,Abbott, Duain E.,Wiley, Michael R.
, p. 139 - 142 (2007/10/02)
The preparation of allylstannanes 1a-c, all of which bear an oxygen substituent at the allylic terminus, is desribed.These reagents react with alpha- and beta-alkoxyaldehydes in the presence of MgBr2 as Lewis acid to give SE' products with diastereofacial selectivity consistent with "chelation control"; a syn disposition of substituents about the newly formed bond is highly favored in all cases.
