Journal of Photochemistry and Photobiology A: Chemistry p. 176 - 182 (2017)
Update date:2022-08-30
Topics:
Nassar, Rania
Trivella, Aurélien
Mokh, Samia
Al-Iskandarani, Mohamad
Budzinski, Hélène
Mazellier, Patrick
The photochemical transformation of two antibacterial sulfonamides, namely sulfamethazine (SMT) and sulfamethoxypyridazine (SMP), and two tricyclic antidepressants, namely amitriptyline (AMT) and clomipramine (CMP) were investigated. Experiments conducted in river water under artificial sunlight irradiation show an acceleration of the degradation for SMT, SMP, and CMP of a factor 1.6–7.7 by comparison to purified water. This acceleration is, at least partially, due to photosensitized reactions which can occur in river water. The photodegradation of CMP was particularly fast. In addition, no degradation was observed for AMT in purified water while photosensitized reaction occurs. Under ultra-violet (254?nm) irradiation in purified water, the four drugs were degraded. Calculated quantum yields of photodegradation were of 4.3?×?10?3, 5.1?×?10?3, 7.6?×?10?3, and 65.0?×?10?3 respectively for SMT, SMP, AMT, and CMP. UV coupled with hydrogen peroxide (UV/H2O2) was used as an advanced oxidation process for water depollution. The calculated second order rate constants of reaction with hydroxyl radicals were of 5.0?×?109, 5.0?×?109, 8.0?×?109 and 9.5?×?109?L?mol?1?s?1 for SMT, SMP, AMT and CMP, respectively. Finally, the structures of photoproducts were proposed according to LC–MS/MS analyses. The elimination of SO2 was the main photochemical process for SMT and SMP. In the case of AMT and CMP, hydration and hydroxylation, respectively, were observed.
View MoreLonzeal Pharmaceuticals Co., Ltd.
website:http://www.lonzeal.com
Contact:+86-13381011962
Address:RM 801, Yue MOMA, No. 26 Anningzhuang Rd. Haidian District, Beijing, China
Hangzhou Yanshan Chemical Co.,Ltd.
Contact:86-571- 87698076
Address:Room 1001, #1 Building, Zhongtian MCC, No.2 Youzhinong, Wenyi West Road, Xihu District, Hangzhou, China
Contact:+44 (0)161 367 9441
Address:
Contact:+86-21-6856-1349 523-87676172
Address:No16 . BinJiang Road . Taixing Economy Developing Area .JiangSu Province . China
Hunan Shineway Enterprise Co., Ltd.
Contact:+86-731-86303875
Address:118, Huanghua International Airport Road, Huanghua Town, Changsha, Hunan 410137, China
Doi:10.1002/anie.202015592
(2021)Doi:10.1021/ic402611m
(2013)Doi:10.1016/j.molstruc.2019.04.119
(2019)Doi:10.1039/c8gc03595d
(2019)Doi:10.1039/d0sc02770g
(2020)Doi:10.1002/anie.201609040
(2016)