Evaluation of desferrithiocin and its synthetic analogues as orally effective iron chelators

Article abstract of DOI:10.1021/jm00111a023

Desferrithiocin, a novel microbial siderophore isolatod from cultures of Streptomyces antibioticus DSM 1865, and a number of its derivatives and analogues are evaluated for their ability to promote iron clearance. The compounds have been designed with the