Coupling reaction of 1-thiopentofuranosides with silylated pyrimidine bases by activation with N-bromosuccinimide: Synthesis of 3'-Azido-3'-deoxythymidine and its related nucleoside analogs

Article abstract of DOI:10.1016/S0040-4039(00)74337-1

3'-Azido-3'-deoxythymidine, 3'-fluoro-3'-deoxythymidine, and their 2'-C-substituted derivatives and L-enantiomers were synthesized by the coupling reaction of the corresponding phenyl 1-thiopentofuranosides with silylated thymine by activation with N-bromosuccinimide.