Aziridinium ions from phenylglycinol - A new approach to the synthesis of chiral diamines

Article abstract of DOI:10.1016/S0040-4039(97)01019-8

A new two-step method [(i) N,N-dialkylation; (ii) aziridinium ion formation followed by amine attack] for the synthesis of chiral diamines from phenylglycinol is described. sequentially without isolation of the intermediate amino alcohols to give diamines in good yields (62-76%). An improved protocol for the N,N-dialkylation of phenylglycinol is also reported.