TETRAZOLES. 31. KINETICS OF THE REACTION OF NITRILES WITH ALKYLAMMONIUM AZIDES. FORMATION OF 5-SUBSTITUTED TETRAZOLES

DOI: 10.1007/BF00531480

Source and publish data:

Chemistry of Heterocyclic Compounds p. 1027 - 1030 (1992)

Update date:2022-08-11

Topics:

Authors:

Ostrovskii, V. A.

Poplavskii, V. S.

Koldobskii, G. I.

Erusalimskii, G. B.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1007/BF00531480

5-Substituted tetrazoles are formed by the reaction of nitriles with mono-, di-, and trialkylammonium azides in aprotic dipolar solvents and alcohols.Tetraalkylammonium azides do not react with nitriles.The formation of 5-substituted tetrazoles occurs by a 1,3-dipolar cycloaddition mechanism.Electron-accepting substituents increase the reactivity of nitriles significantly while the structure of the alkylammonium azide and the solvent polarity have no significant effect on the reaction rate.

Full text of DOI:10.1007/BF00531480

Products guided by the article

Product name:dimethyl[2-(1H-1,2,3,4-tetrazol-5-yl)ethyl]amine

Cas No:116822-26-5

R&D Labs maybe for 116822-26-5

Shanghai Yudiao Chemistry Technology Co.,Ltd

Contact:0086-18964703211

Address:Building NO.5, NO.218,Rongtian Road,ganxiang town,Jinshan District,shanghai,201518,china
VanderArk International Limited

Contact:86-10-82437576

Address:Qing He
Beijing Green Guardee Technology CO,.LTD

Contact:+86-10-69706062

Address:F2 BLdj,5 No.37 Chaoqian Road
Xinchang Jiu Xin Pharmaceutical Co., Ltd

website:http://www.jiuxinpharm.com

Contact:86 137 5756 8585

Address:Poyang industry Park
Weihao Chemtech (ChangZhou) Co., Ltd.(expird)

Contact:051989185693

Address:NO 217 huangshan Rd ,Changzhou

Relevant to this article

Efficient separation of diastereomeric mixtures of syn - And anti -2,4-pentanediol

Doi:10.1021/acs.oprd.5b00043
(2015)
Photochemical Reactions in Polyethylene Glycol. 2. Photo-induced Nucleophilic Substitution of Dimethoxybenzenes in the Presence of Polyethylene Glycol

Doi:10.1246/bcsj.55.3349
(1982)
Ultrasound-accelerated synthesis of 1,4-dihydropyridines in an ionic liquid

Doi:10.1007/s00706-005-0405-9
(2006)
Facile synthesis of 5'-deoxy- and 2',5'-dideoxy-6-thiopurine nucleosides by nucleoside phosphorylases

Doi:10.1016/S0040-4020(98)00476-1
(1998)
MECHANISM OF THE REACTION OF 3,5-DINITROBENZONITRILE WITH SODIUM METHOXIDE IN METHANOL.

Doi:10.1246/bcsj.56.1206
(1983)
One-Pot Four Component Synthesis of 3-Amino-1-(1H-indol-2-yl)-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1,2-b]phthalazine Derivatives Mediated by [DBUH][OAc]

Doi:10.1134/S1070363218090219
(2018)

Article Doi