Tetrahedron p. 8661 - 8670 (1998)
Update date:2022-08-11
Topics:
Chae, Whi-Gun
Chan, Thomas C. K.
Chang, Ching-Jer
5'-Deoxy-6-thioguanosine, 2',5'-dideoxy-6-thioguanosine, 5'-deoxy-6- mercaptopurine riboside and 2',5'-dideoxy-6-mercaptopurine riboside were synthesized enzymatically from thiopurine bases and corresponding ribosyl donors using nucleoside phosphorylase. This is the first report of trans-5'- deoxyribosylation to thiopurine bases by nucleoside phosphorylase. 5'-Deoxy- 6-thioguanosine selectively blocked the growth of v-ras-transformed human bronchial epithelial cells. In addition, the in vitro antitumor cytotoxicity data for 5'-deoxy- and 2',5'-dideoxy-6-thiopurine nucleosides were comparable to those for the corresponding thiopurine bases.
View More
Tianjin Bright Future Technology Co., Ltd
Contact:0086-22-58016666
Address:NO.136 DongTeng Lake Street Tianjin Economic and Technology Development Area,Tainjin,China
Huangshan Violet Biological Technology Co., Ltd
Contact:+86-559-2335676
Address:16-201 JinShanYuan,JiangNan New City,TunXi District,HuangShan City,AnHui Province,China
Contact:+86-18653358619
Address:zibo
Nanjing Ruizhi Industry & Technologh Co.，Ltd.
Contact:+86-25-86808110
Address:441-4-A5,NO.12 Longzang Avenue,Yuhuatai District,210039,Nanjing
Contact:(86) 731 88718666
Address:Room 1222, Unit 4, Building B, Shangcheng, No.47, Kaiyuan East Road.
Doi:10.1016/j.steroids.2006.03.004
(2006)Doi:10.1016/0022-4596(84)90003-3
(1984)Doi:10.1211/096089296765556980
(2000)Doi:10.1016/S0040-4039(00)79654-7
(1991)Doi:10.1016/j.tetlet.2005.01.116
(2005)Doi:10.1016/S0031-9422(00)80167-3
(1983)
