Synlett p. 1351 - 1354 (2010)
Update date:2022-08-16
Topics:
Wang, Tao
Huang, Xian-Gui
Liu, Jia
Li, Bo
Wu, Jin-Jin
Chen, Kai-Xian
Zhu, Wei-Liang
Xu, Xiao-Yong
Zeng, Bu-Bing
An efficient one-pot procedure for the direct catalytic synthesis of substituted 2-aminothiophenes catalyzed by l-proline under mild reaction conditions has been developed. A variety of functionalized 2-aminothiophene scaffolds were assembled in high yields by this catalytic protocol. Low catalyst loading, simple procedure, and high yields are the important attributes of this methodology.
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