Practical synthesis of (2S,3S)-3-amino-2 hydroxy-4-phenylbutyric acid, a key component of HIV protease inhibitors

DOI: 10.1248/cpb.46.733

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 733 - 735 (1998)

Update date:2022-08-16

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Authors:

Shibata, Norio

Itoh, Etsuko

Terashima, Shiro

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Article abstract of DOI:10.1248/cpb.46.733

Synthesis of (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid was achieved by the highly diastereoselective cyanohydrin formation of (S)-2-N,N- dibenzylamino-3-phenylpropanal with acetone cyanohydrin in the presence of trimethyl-aluminum as a key step.

Full text of DOI:10.1248/cpb.46.733

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