Design of chiral phase transfer catalyst with conformationally fixed biphenyl core: Application to asymmetric alkylation of glycine derivatives

Article abstract of DOI:10.1021/op0602324

Chiral phase transfer catalysts (S)-1a and (S)-1b with a conformationally fixed biphenyl core were conveniently prepared from the known (S)-6,6′-dimethylbiphenyl-2,2′-diol 2 in five steps. These catalysts, (S)-1a and (S)-1b, are readily applicable to asym