Vinylsilane-terminated cycloacylation: A general synthetic approach to four- to six-membered cyclic ketones and its regiochemical features

Article abstract of DOI:10.1016/S0040-4020(01)91006-3

Intramolecular acylations of m-trimethylsilyl-m-alkenoyl chlorides (m = 4 and 5) are described which afford the expected α-alkylidenecycloalkanone and/or the unexpected cycloalkenone, depending markeldy upon the substitution pattern on the vinylsilane moiety and/or the chain length (m).