Tetrahedron Letters p. 5537 - 5540 (1999)
Update date:2022-08-10
Topics:
Itami, Kenichiro
Mitsudo, Koichi
Yoshida, Jun-ichi
(2-Pyridyldimethylsilyl)methyl lithium was found to react with organic bromides, aldehydes, ketones, and hydrosilanes in good to excellent yields. The resultant adducts were further oxidized with H2O2/KF to give the corresponding alcohols in excellent yields. Thus, this two-step transformation provides an efficient method for hydroxymethylation.
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