Tetrahedron Letters p. 3021 - 3024 (1994)
Update date:2022-08-17
Topics:
Roberts, Ralph R.
Landor, Stephen R.
Bolessa, Evon A.
Ethyl alka-2,3-dienoates and 4-tetrahydropyranyloxyalk-2-ynenitriles provide a 3-atom fragment when reacted with acetamidine in tetrahydrofuran, to furnish-2-methylpyrimidin-4(3H)-ones and 4-amino-2-methyl-6-(1-tetrahydropyranyloxyalkyl)pyrimidines, respectively (60-70% yield). The latter, with hydrochloric acid/ethanol, gave the corresponding 4-amino-6-(1-hydroxyalkyl-2-methylpyrimidines as their hydrochloride salts.
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