Solution phase preparation of highly pure amide mixtures via in-situ chlorotrimethylsilane protection and activation

Article abstract of DOI:10.1080/00397919708004209

Coupling of 4-(4-aminophenyl)butyric acid 1 with acyl halides in both organic and aqueous media were found to produce large amount of oligomeric materials. By using an in situ chlorotrimethylsilane protection/activation procedure, these oligomers were sup

Full text of DOI:10.1080/00397919708004209

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Synthetic Communications:
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Solution Phase Preparation
of Highly Pure Amide
Mixtures via In-Situ
Chlorotrimethylsilane
Protection and Activation
Koc-Kan Ho a b , Nai Fang Wang a , Christine
Lercara a , Doris C. O'Toole a , Douglas M. Achan
a , Edmund A. Vuocolo a & Andrea Leone-Bay a
a Emisphere Technologies Inc., 15 Skyline Dr.,
Hawthorne, NY, 10532
b Pharmacopeia, Inc., 101 College Road East,
Princeton, NJ, 08540
Version of record first published: 22 Aug 2006
To cite this article: Koc-Kan Ho, Nai Fang Wang, Christine Lercara, Doris
C. O'Toole, Douglas M. Achan, Edmund A. Vuocolo & Andrea Leone-Bay
(1997): Solution Phase Preparation of Highly Pure Amide Mixtures via In-Situ
Chlorotrimethylsilane Protection and Activation, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry,
27:5, 883-895
To link to this article: http://dx.doi.org/10.1080/00397919708004209

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