Renin inhibitors. III. Synthesis and structure-activity relationships of transition-state inhibitors containing dihydroxyethylene isostere at the P1- P(1') site

DOI: 10.1248/cpb.42.306

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 306 - 313 (1994)

Update date:2022-08-10

Topics:

Authors:

Atsuumi Atsuumi

Funabashi

Nakano Nakano

Koike Koike

Tanaka Tanaka

Harada Harada

Matsuyama

Ikenaga Ikenaga

Morishima

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Article abstract of DOI:10.1248/cpb.42.306

The design, synthesis and structure-activity relationships of transition- state inhibitors containing the dihydroxyethylene isostere at the scissile site are described. The compounds with (2S,3R,4S)-4-amino-5-cyclohexyl-1- morpholino-2,3-pentanediol at th

Full text of DOI:10.1248/cpb.42.306

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