Tetrahedron Letters p. 7925 - 7928 (1999)
Update date:2022-08-11
Topics:
Hulme, Christopher
Ma, Liang
Romano, Joseph
Morrissette, Matthew
This communication reveals the novel solution phase synthesis of an array of biologically relevant imidazolines in a remarkable 'three-step-one-pot' procedure, utilizing a Ugi/de-Boc/cyclization (UDC) strategy. Transformations are carried out in excellent yield by condensation of N-Boc-α-amino-aldehydes and supporting Ugi reagents. The described protocol represents a highly attractive solution phase procedure for the rapid generation of this class of molecule.
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