Synthesis p. 569 - 570 (1986)
Update date:2022-08-11
Topics:
Neumann, Ronny
Sasson, Yoel
The para selectivity of the Reimer-Tiemann reaction was increased by use of polyethylene glycol in the reaction medium.The polyethylene glycol complexes the phenolate substrate masking the ortho position of the benzene nucleus increasing para selectivity without affecting the total yield.
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