Synthesis of Fluorine Analogues of Protoporphyrin

Article abstract of DOI:10.1016/S0022-1139(00)82758-X

With intention of obtaining a porphyrin derivative useful for diagnosis and therapy of cancer, fluorine analogues of protoporphyrin, in which the vinyl group(s) are replaced by difluorovinyl group(s), were synthesized by the reaction of the formylporphyrins with sodium chlorodifluoroacetate in the presence of triphenylphosphine.