Journal of Organic Chemistry p. 6255 - 6265 (1993)
Update date:2022-08-16
Topics:
Gilbert, John C.
Selliah, Robert D.
An enantioselective synthesis of trichodiene 1 has been accomplished.The key bond between the vicinal quaternary centers is formed by way of an Ireland-Claisen rearrangement of the ketene silyl acetal 24.The rearrangement occurs with complete facial selectivity and excellent diastereoselectivity to give an advanced intermediate that is directly converted to ent-trichodiene, (-)-1.
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